Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats
The root of Enantia chlorontha was assayed for its hepatotoxicity effect. Extacts from the root were made using 95% ethanol. The root extracts were administered orally to 15 wistar albino rats and varying doses. 5 rats were kept as control group. The effect of the extracts was determined by assaying for the levels of serum-liver enzymes acting as biochemical makers. Liver enzymes assayed included Aspartate aminotransferase (AST), Alanin aminiotransferase (ALT) and alkaline phophatase (ALP). Comparison of the enzyme levels of the control group with these of the group administered with the rot extract revealed a significant elevation of liver enzyme levels
Title Page i
Certification ii
Dedication iii
Acknowledgement iv
Table Of Content i
Abstract ix
Chapter One
1.0 Introduction 1
1.1 Background Of The Study 1
1.2 Aims And Objectives 6
1.3 Statement Of Problem 7
1.4 Limitation Of Study 7
1.5 Significance Of The Study 8
Chapter Two
2.0 Literature Review 9
2.1 General Description Of Enantia Chlorontha 10
2.2 Ecological Distribution Of Enantia Chlorantha 10
2.3 Management And Propagation Practices 11
2.4 Functional Uses 12
2.5 Toxicity 13
2.6 Hepatotoxicity 17
2.7 Liver 20
2.7.1 Liver Enzyme 22
2.7.2 Some Pattern Of Liver Injury 23
2.7.3 Treatment/Prognosis Of Liver Damage 28
2.8 The Albino Rats 29
2.9 Phytochemical Compounds 31
Chapter Three
3.0 Materials And Methods 32
3.1 Collection, Identification And Processing Of Plant Material 32
3.1.1 Extraction Of Plant Material 33
3.1.2 Determination Of The Weight Of Dried Extract 34
3.2 Phytochemcial Analysis 35
3.3 Experimental Animal 43
3.4 Determination Of Dosage Of The Plant Extract For Animal Feeding 43
3.5 Grouping Of Animal And Administration Of Plant Extract 44
3.6 Feeding Method 45
3.7 Procedures For Blood Sample Collection 46
3.7.1 Alanine Aminotransferase Test (Alt) Method For Alt Test 47
3.7.2 Aspartate Animotransferase: (Ast) Method For Ast Test 48
3.7.3 Alkaline Phousphatase: (Alp) Method For Alp Test 49
Chapter Four
4.0 Results 50
4.1 Result Of The Photochemical Analysis Of The Ethanolic Extract Of Enantia Chlorontha 50
4.2 Hepatotoxicity Assay 55
Chapter Five
5.1 Discussion 58
5.2 Conclusion 60
5.3 Recommendation 60
References 61
The Title Page should be the first section of your project “Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats”, providing essential details like the project title, your name, your supervisor’s name, the institution, and the submission date. After that, the Abstract offers a brief summary of your project, touching on its purpose, methods, results, and conclusions in 150-300 words. The Acknowledgments section is where you can thank those who supported your research, such as your supervisor, peers, or organizations that provided resources.
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The main body of the Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats should start with the Introduction, which provides background information, outlines the research problem, states your objectives, and gives a brief overview of your research methods. Following that, the Literature Review offers an in-depth look at previous research relevant to your project, identifying gaps your study aims to address. The Methodology section then explains the research design, tools, and data collection methods you used to conduct the project and analyze the data.
In the Results and Discussion section, you present your findings and discuss them in relation to the Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats research questions or objectives, often using tables or charts to help explain the data. The Conclusion summarizes the key results, discusses their implications, and suggests possible directions for future research. You may also include recommendations based on your findings, offering practical advice for improvements or applications. Finally, the Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats project should include a References or Bibliography section to list all the sources you cited, as well as Appendices for any additional material. A Statement of Originality is often included to confirm the authenticity of your work